cycle and apoptosis induction after irradiation Biology Diagrams The key proteins involved in cell cycle checkpoints in different phases of the cell cycle, and their interaction, is a fertile and rapidly developing area of research. This review summarizes the current state of knowledge of cellular checkpoints in response to radiation-induced double-strand breaks in mammalian cells and how this impacts on
Although understanding the concept of the cell-cycle phase is important to understanding ionizing radiation's effect on the cell, the therapeutic application of synchronization is extremely limited. Concerns about the therapeutic efficacy of synchronization therapy have come from a number of sources (199, 231-234). For example, Tubiana et al.
Role of cell cycle in mediating sensitivity to radiotherapy Biology Diagrams
Cell cycle progression can be studied with computational models that allow to describe and predict its perturbation by agents as ionizing radiation or drugs. Such models can then be integrated in Multiple pathways are involved in maintaining the genetic integrity of a cell after its exposure to ionizing radiation. Although repair mechanisms such as homologous recombination and nonhomologous end-joining are important mammalian responses to double-strand DNA damage, cell cycle regulation is perhaps the most important determinant of ionizing radiation sensitivity.
Key words: health effects; radiation damage; radiation protection; radiation, ionizing. INTRODUCTION. T he direct effect of ionizing radiation on the human body is typically manifested as a cytological effect, the worst of which is cell death. It is important to identify the mode of cell death caused by ionizing radiation and its molecular
Biological effects of radiation on cancer cells Biology Diagrams
Comparing isodoses, high-LET irradiation is a more potent inducer of cell cycle delays than low-LET irradiation. Generally, more pronounced delays in S- and G2-phase have been observed with increasing LET. The role of TP53 in relation to these effects is still controversial. A dose- and LET- depende โฆ
